7-Keto DHEA

By | June 22, 2009

Earlier I wrote about DHEA and how it was doing me some good physically; today, I am going to give an update and further info on 7-Keto DHEA (3-acetyl-7-oxo-dehydroepiandros-terone) going on one and a half months into my experience on using it. 7-Keto is basically another form of DHEA, albeit a more readily available form of DHEA for the body; therefore, it is supposed to be more potent than DHEA itself.

Firstly, 7-Keto is a natural metabolite of DHEA. Studies so far on lab animals have shown positive benefits as demonstrated by stimulation of their immune systems, increasing their metabolic rates, and reducing muscle catabolism, among others. But long term human-based test results are more limited, although they also point to positive benefits in humans, and toxicology tests on rats and monkeys also indicate the high tolerance factor for 7-Keto by the body. You would literally have to take many tens of thousands of milligrams of 7-Keto per day for it to become toxic to your body.

That does not mean you should simply take 7-Keto at high doses (read Precautions below). Most of the conclusive human based trial results which we now have came from the research of Dr Arlene Morales and Samuel Yen back in the 1990s. Newer research is needed, I feel.

7-keto-dheaRight now, I think 7-Keto is promoted more by weight loss proponents for its weight loss potential rather than for its anti aging properties, as 7-Keto does increase fat burning enzymes in the liver, which makes it “thermogenic.” As we humans age, metabolic rates tend to slow down, and activity levels drop as a result of declining energy, and this often results in weight gain (for example the spare tires around the waist in middle aged people). Taking some 7-Keto and engaging in daily exercise may be the formula for weight maintenance in middle aged people.

Among other claims made for 7-Keto are its cholesterol lowering and memory enhancing benefits. Among its purported effects on cholesterol are increasing good HDL cholesterol, and lowering bad LDL cholesterol. It has also been indicated as a potential memory enhancer based on results done with lab mice that were subjected to a water maze test. Further details on 7-Keto’s benefits are expounded here.

Is 7-Keto a much better version of DHEA?

I do not know the full answer to this, as in my 1.5 months experience of taking 7-Keto I still feel that conventional DHEA provided the most tangible benefits; whereas 7-Keto did not add anything significant to the mix (or at least nothing tangible). What I am doing is dividing my doses with DHEA in the morning, 7-Keto in the afternoon, and DHEA at night, plus an HGH releaser before bedtime. Take note that this is in conjunction with some sensible cycling (taking a couple of consecutive days off on a weekly basis), plus lots of exercise on a regular basis.

If you take 7-Keto in addition to normal DHEA, you should reduce your normal DHEA consumption, because 7-Keto is actually a much more concentrated form of DHEA, and the body utilizes it straight away without having to convert it into either testosterone or estrogen, as it does with conventional DHEA. Since including some 7-Keto, I have reduced my DHEA intake. I only take 25 mg of 7-Keto and stay away from high doses (some 7-Keto doses are formulated at 100 mg and above). I would strongly advise everyone who intends to take 7-Keto, to do the same – stick to low doses and cycle off periodically (take off 2 days in a week).


7-Keto has been implicated in cases of tachycardia (rapid heartbeat), and other unpleasant symptoms of elevated androgenic and estrogenic levels (still), like hair loss, acne, facial hair growth, and other similar side effects of DHEA overdosage. So although it is still marketed as a “safe” metabolite of DHEA, one should always exercise care and caution in taking 7-Keto. Like DHEA, there is still a lot that we do not know about with reagrds to any potential side effects both short term, and long term. So it is always best to err on the side of caution, as in all things.